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Valley fever hit epidemic proportions last year and experts are wondering if 2002 will be a repeat.

If the disease infects anywhere near the same number of Kern County residents as it did in the early 1990s, the cost could be staggering. During the epidemic years of 1991-93, valley fever costs mounted to more than $56 million. A similar outbreak now could mean even greater costs.

Researchers are making progress toward a vaccine, but the going has been slow. The Californian examines the impact of the disease and the efforts of those ìFighting the Fever.î


                                                                      --------1892
                                                                                 Domingo Escurra, an Argentinian                                                                                  soldier, first reported case.                                                                                  Discovered at a Buenos Aires                                                                                  hospital.

                                                                      --------1893
                                                                                 Joas Furtado-Silveira, a Portuguese                                                                                  farm laborer who worked in the San                                                                                  Joaquin Valley, first North American                                                                                  case, dies at San Francisco                                                                                  hospital.

                                                                      --------1894
                                                                                 JosÈ Teixara Pereira, another                                                                                  Portuguese farm worker, dies.                                                                                  Doctors suspect a parasite and call                                                                                  it Coccidioides immitis.

                                                                      --------1900
                                                                                 Coccidioides immitis discovered to                                                                                  be a fungus.

                                                                      --------1905
                                                                                 Reports state people inhale fungal                                                                                  spores to get the disease, termed                                                                                  "coccidiodal granuloma."

                                                                      --------1910
                                                                                 Immigrants to the San Joaquin                                                                                  Valley develop flu-like illness known                                                                                  as valley fever, or San Joaquin fever.

                                                                      --------1932
                                                                                 The Kern County Health                                                                                  Department reports non-whites                                                                                  develop more serious cases.

                                                                      --------1932
                                                                                 First published case in Mexico.

                                                                      --------1932
                                                                                 Tests for valley fever detection are                                                                                  developed.

                                                                      --------1937
                                                                                 First Arizona case diagnosed.

                                                                      --------1940s
                                                                                 Outbreaks among U.S. Army                                                                                  soldiers in the San Joaquin Valley                                                                                  and in Arizona. Outbreaks in                                                                                  Japanese internment and                                                                                  prisoner-of-war camps. Skin tests                                                                                  performed on U.S. Airmen in the                                                                                  Valley.

                                                                      --------1948
                                                                                 First reported case in a pregnant                                                                                  woman.

                                                                      --------1950s
                                                                                 U.S. military classifies cocci as a                                                                                  biological weapon. Amphotericin B                                                                                  introduced as the first effective                                                                                  treatment.

                                                                      --------1960s
                                                                                 Experimental vaccines found                                                                                  effective in mice and monkeys. UC                                                                                  Berkeley researchers inject                                                                                  themselves with the vaccine.                                                                                  Vacaville Prison inmates injected                                                                                  with the vaccine.

                                                                      --------1970s
                                                                                 Outbreak among Vietnamese                                                                                  refugees in California.

                                                                      --------1977
                                                                                 Dust storm carries cocci spores all                                                                                  the way to San Francisco Bay area.

                                                                      --------1980s
                                                                                 Valley fever vaccine trials on                                                                                  humans. Participants complain of                                                                                  arm pain and other side effects.

                                                                      --------1991
                                                                                 First year of Kern County epidemic                                                                                  with 1,181 cases.

                                                                      --------1992
                                                                                 Epidemic reaches peak with 3,342                                                                                  cases and 25 deaths.

                                                                      --------1994
                                                                                 Official end of 4-year epidemic.                                                                                  Outbreak of valley fever in Ventura                                                                                  County, following the Northridge                                                                                  Earthquake. New anti-fungal drugs                                                                                  available.

                                                                      --------1995
                                                                                 Valley Fever Center for Excellence in                                                                                  Tucson, Ariz., founded.

                                                                      --------2000s
                                                                                 Cocci proteins identified that could                                                                                  be used for a future vaccine.                                                                                  Proteins tested on animals.

                                                                      --------2001
                                                                                 Number of valley fever cases                                                                                  rises dramatically in Arizona and                                                                                  San Joaquin Valley.

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